Despite the RG name, the RG50 has the rounded-edge body style and swoopy, rounded headstock of the older Roadstar II body. It is one of only a small number of RG models with a humbucker/ single/ single pickup configuration. It has a tone chamber routed out of the body beneath the pickguard.
The RG50 features a chambered basswood body bolted to a maple neck with a 24-fret rosewood fingerboard with dot position markers. Components include Ibanez pickups with a Super 70 humbucker with Duo-Sound coil split functionality at the bridge and Super 7F single-coils in the neck and middle positions and a Powerocker Special tremolo bridge.