The RG450DXB features a mahogany body bolted to a one-piece maple Wizard III neck with a 24-fret rosewood fingerboard with binding and sharktooth position markers. Components include Ibanez Quantum pickups, a standard double locking tremolo bridge and a locking nut.
For 2018 the rosewood fretboard was replaced with jatoba. For 2019 the mahogany body was replaced with meranti.
The RG450DXBL is a left-handed version. The RG450DX is a similar model with cosmo black hardware and a black finish. The RG450EXB is a very similar spot model with different finishes and a black pickguard which was introduced in 2019 as an exclusive for Guitar Center and Musician's Friend.