RG421 is a model name which has been applied to several distinct RG series guitar models. Features common to all these RG421 variants include an RG-style body, a pair of humbucking pickups), an All Access Neck Joint, and a fixed bridge.
RG421 commonly refers to one of these models:
- RG421 (2002); made in Japan, basswood body, GTC Jr. bridge, Ibanez V7/V8 pickups, rosewood fretboard
- RG421 (2013–2023); made in Indonesia, mahogany (2013–2018) or meranti (2019–2023) body, maple neck, rosewood (2013–2017) or jatoba (2018–2023) fretboard, fixed bridge or F106 bridge, Infinity or Quantum pickups in pickup rings
- RG421 (2024); made in Indonesia, meranti body, maple neck, jatoba fretboard, F106 fixed bridge, direct-mounted Quantum pickups, mono-unit output jack
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